A Grammar Inference Approach for Predicting Kinase Specific Phosphorylation Sites
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چکیده
منابع مشابه
A Grammar Inference Approach for Predicting Kinase Specific Phosphorylation Sites
Kinase mediated phosphorylation site detection is the key mechanism of post translational mechanism that plays an important role in regulating various cellular processes and phenotypes. Many diseases, like cancer are related with the signaling defects which are associated with protein phosphorylation. Characterizing the protein kinases and their substrates enhances our ability to understand the...
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Protein phosphorylation is one of the most significant and well-studied post-translational modifications, and it plays an important role in various cellular processes. It has made a considerable impact in understanding the protein functions which are involved in revealing signal transductions and various diseases. The identification of kinase-specific phosphorylation sites has an important role...
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MOTIVATION Phosphorylation is a crucial post-translational protein modification mechanism with important regulatory functions in biological systems. It is catalyzed by a group of enzymes called kinases, each of which recognizes certain target sites in its substrate proteins. Several authors have built computational models trained from sets of experimentally validated phosphorylation sites to pr...
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The protein phosphorylation is one of the important processes in the cell signaling pathway. A variety of protein kinase families are involved in this process, and each kinase family phosphorylates different kinds of substrate proteins. Many methods to predict the kinase-specific phosphoryrated sites or different types of phosphorylated residues (Serine/Threonine or Tyrosin) have been developed...
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Models based on Chomskyan grammar are not as pervasive in certain NLP applications as might be expected from their status in linguistics, comparing to, e.g., statistical n-gram models or vector space models. In contrast, here grammar inference is approached from the viewpoint of constructionist theories of language, which avoid the separation of morphology, syntax, semantics and pragmatics. We ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0122294